Principal Associate Scientist, DTD

**Principal Associate Scientist, Discovery \& Translational Development – Solid Biosciences** **Charlestown, MA** Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2\-mediated dilated cardiomyopathy, BAG3\-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient\-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. We are seeking a highly skilled and motivated bench scientist to join the Discovery \& Translational Development team to support our clinical and pre\-clinical programs. The ideal candidate will have a strong scientific background in mammalian cell culture, assay development, and molecular biology. Reporting to the Senior Principal Scientist, Scientific Lead, this is an on\-site position based out of Solid’s headquarters in Charlestown, MA. **Responsibilities** **Technical Execution** * Develop AAV functional potency assays by transfecting, transducing, and/or engineering mammalian cell lines * Develop molecular assays (ddPCR, ProteinSimple Jess) and cell\-based assays to assess expression cassettes and AAV potency * Develop ELISA and MSD assays to identify novel biomarkers using patient and nonclinical samples * Support oversight and review or CRO activities * Maintenance of electronic lab notebook (ELN) documenting experimental procedures, materials, reagents, and data * Data Analysis: Independently analyze experimental data accurately and efficiently, drawing valid conclusions. * Lab Maintenance: Ensure proper maintenance of laboratory equipment and ensure a safe working environment. **Cross\-Functional Support** * Collaborative Projects: Participate in projects across different programs, providing expertise where needed. * Knowledge Sharing: Share findings and methodologies with peers to foster a collaborative environment. Provide guidance/mentorship to junior scientists. * Flexibility: Adapt to shifting priorities and contribute to multiple projects as required. **Compliance and Quality Assurance** * Regulatory Compliance: Conduct all activities in accordance with regulatory guidelines and company policies. * Quality Standards: Ensure all experimental procedures meet quality standards. * Documentation: Maintain accurate and detailed records of all experiments and results. **Communication** * Reporting: Communicate progress and results to scientific leads and team members regularly. * Team Meetings: Participate actively in team meetings, providing updates and insights. Effective communication and interpretation of complex scientific subjects to all audiences. * Interpersonal Skills: Build positive working relationships within the team and across the organization. Apply learnings from the broader organization as they relate to the project team. **Required Qualifications** * MS in Biology or related discipline with 5\+ years of industry experience or BS with 7\+ years of industry experience * Background in Friedreich’s ataxia and mitochondrial biology is preferred * Proficiency with mammalian cell culture, cell line engineering, and/or iPSC differentiation, and experience with transfection or AAV transduction * Proficient in quantitation of DNA, RNA, and protein expression by ddPCR, qPCR, ProteinSimple Jess, ELISA, and MSD * Software proficiency including Geneious, SnapGene, NCBI, BLAST, Ensembl, GraphPad Prism, Benchling, and Microsoft Office Suite * Ability to work independently and collaboratively * Strong organizational, written, and verbal communication skills **Compensation** The base compensation range for this role is: $110,000 – 125,000 Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills \& experience, job location, and internal equity. Regular employees are eligible to receive both short\-term and long\-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. **Benefits and Solid Advantages** At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well\-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices. * Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs * 401(k) program participation with competitive company matched contributions * Eligibility to participate in Solid’s Employee Stock Purchase Plan * Mobile phone subsidy for eligible employees * Tuition Reimbursement * Vision Coverage * Life Insurance * Voluntary Pet Insurance * Employee Discount Program on Travel, Entertainment, and Services * Employee Assistance Programs * Daily Subsidized Lunch Delivery (onsite @ Hood Park) * Free Onsite Full\-Service Gym (onsite @ Hood Park) * Employee Parking (onsite @ Hood Park) * 12 Observed Holidays and a winter shut down * 15\-day PTO Policy and an 80\-hour rollover YoY * 40\-hour Sick Policy * 8 Hour Floating Holiday